DROSOPHILA NANOS ACTS AS A MOLECULAR CLAMP THAT MODULATES THE RNA-BINDING AND REPRESSION ACTIVITIES OF PUMILIO

Drosophila Nanos acts as a molecular clamp that modulates the RNA-binding and repression activities of Pumilio

Collaboration among PRO MG 12 MIXED BERRY the multitude of RNA-binding proteins (RBPs) is ubiquitous, yet our understanding of these key regulatory complexes has been limited to single RBPs.We investigated combinatorial translational regulation by Drosophila Pumilio (Pum) and Nanos (Nos), which control development, fertility, and neuronal functions

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